neutrophil storage pool - PMC

Darko Stojkov, Lea Gigon, Shuang Peng, Robert Lukowski, Peter Ruth, Alexander Karaulov, Albert Rizvanov, Nickolai A. Barlev, Shida Yousefi, Hans-Uwe Simon

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What Is the Evolutionary Fingerprint in Neutrophil Granulocytes?

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Int J Mol Sci. 2020 Jun; 21(12): 4523. Published online 2020 Jun 25. doi: 10.3390/ijms21124523

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Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex and age-related functional regulation

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Neutrophils in physiology and pathology

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Annu Rev Pathol. Author manuscript; available in PMC 2024 May 1.

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A metabolic perspective of the neutrophil life cycle: new avenues in immunometabolism

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Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone- and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and Storage

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Neutrophil diversity and plasticity: Implications for organ transplantation

Junwen Qu, Jingsi Jin, Ming Zhang, Lai Guan Ng

Cell Mol Immunol. 2023 Sep; 20(9): 993–1001. Published online 2023 Jun 29. doi: 10.1038/s41423-023-01058-1

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Neutrophil migration in infection and wound repair: going forward in reverse

Sofia de Oliveira, Emily E. Rosowski, Anna Huttenlocher

Nat Rev Immunol. Author manuscript; available in PMC 2017 Mar 27.

Published in final edited form as: Nat Rev Immunol. 2016 May 27; 16(6): 378–391. doi: 10.1038/nri.2016.49

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Necroptosis triggers spatially restricted neutrophil-mediated vascular damage during lung ischemia reperfusion injury

Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit I. Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel

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Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun

Cell Transplant. 2024 Jan-Dec; 33: 09636897241228031. Published online 2024 Feb 14. doi: 10.1177/09636897241228031

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Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease

Vincent D. Giacalone, Camilla Margaroli, Marcus A. Mall, Rabindra Tirouvanziam

Int J Mol Sci. 2020 Feb; 21(3): 851. Published online 2020 Jan 28. doi: 10.3390/ijms21030851

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Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic E. coli Challenge

Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi, John B. G. Mackey, Charlotte Dean, James A. Harker, Leo M. Carlin, Sara Rankin, Katia De Filippo

Front Immunol. 2021; 12: 597595. Published online 2021 Apr 19. doi: 10.3389/fimmu.2021.597595

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PMC Images search for neutrophil storage pool

Figure 13-18

Mechanisms of Neutrophilic Leukocytosis.
1, Neutrophils and their precursors are distributed in five pools: a bone marrow precursor pool, which includes mitotically active and inactive immature cells; a bone marrow storage pool, consisting of mitotically inactive mature neutrophils; a peripheral blood marginating pool; a peripheral blood circulating pool; and a tissue pool. The relative size of each pool is represented by the size of its corresponding wedge. The peripheral blood neutrophil count measures only neutrophils within the circulating peripheral blood pool, which can be enlarged by (2) increased demargination, (3) diminished extravasation into tissue, (4) increased release of cells from the marrow storage pool, and (5) expansion of the marrow precursor pool.

Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System

Pathologic Basis of Veterinary Disease. 2017 :724-804.e2.
Figure 1

The CXCL12/CXCR4 neutrophil retention axis. There is a substantial storage pool of mature neutrophils in the bone marrow termed the bone marrow reserve. Under homeostasis, neutrophils are retained in the bone marrow due to the constitutive production of CXCL12 by stromal cells and expression of CXCR4 by neutrophils. Genetic deletion of CXCR4 in myeloid cells (CXCR4MKO) results in depletion of the bone marrow reserve with a rise in circulating neutrophil numbers. In WHIM syndrome, a genetic mutation of CXCR4 increases the activity of the receptor, thereby enhancing neutrophil retention in the bone marrow and reducing numbers in the blood

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease

Eur J Clin Invest. 2018 Nov;48(Suppl Suppl 2):e12949.
FIGURE 4-3

Neutrophil compartments in the body. Neutrophils in various areas of the body are grouped into pools for evaluation. The bone marrow cells are divided into the mitotic, maturation, and storage pools (see text). Neutrophils in blood are either in the circulating pool, which is sampled by a complete blood count (CBC), or the marginal pool, which is hidden from sampling via the CBC. Neutrophils move in one direction into the tissues, where they can be evaluated by cytology or histopathology.

Leukocyte Disorders

Small Animal Clinical Diagnosis by Laboratory Methods. 2012 :63-91.
FIGURE 4-3

Neutrophil compartments in the body. Neutrophils in various areas of the body are grouped into pools for evaluation. The bone marrow cells are divided into the mitotic, maturation, and storage pools (see text). Neutrophils in blood are either in the circulating pool, which is sampled by a complete blood count (CBC), or the marginal pool, which is hidden from sampling via the CBC. Neutrophils move in one direction into the tissues, where they can be evaluated by cytology or histopathology.

Leukocyte Disorders

Small Animal Clinical Diagnosis by Laboratory Methods. 2004 :63-91.